How to Use Retin-A Tretinoin for Anti-Aging, Acne and Wrinkles

retin-a for acne and wrinkles

One of our most popular prescription medications for acne in dermatology is tretinoin (1) (Retin A). Why? Because it works well and it is also one of the most powerful skin care products in the war against aging skin. It's tricky to use though. I'm a big tretinoin fan and here I'll give you tips from my practice for how to use tretinoin with a lower risk of skin irritation and dryness.

Why are Tretinoin Anti-Aging Products so Popular?

  • Many scientific studies, and my own experience utilizing tretinoin anti-aging creams  personally and in my practice, have shown these powerful results:

    • Tretinoin has proven itself to reduce, reverse and prevent wrinkles. (The younger a person starts using it, meaning in their teens and twenties, the more benefits they receive. But, it’s never too late to start using it!)
    • Tretinoin helps lighten and prevent age spots.
    • Tretinoin builds collagen to thicken and increase the structural strength of treated skin.
    • Tretinoin helps fight crepey skin.
    • Skin just looks better and younger when people use tretinoin.


  • Using Tretinoin for anti-aging is effective but it also has many other amazing benefits for your skin!

dermatologist Dr. Bailey's tips to use tretinoinI love tretinoin and have personally used it for over 32 years. My skin looks better now than it did then! I've also written thousands of prescriptions for it during this same time and I've helped the same number of patients integrate it into their skin care treatments.

Dermatologist Cynthia Bailey, MD

When to Start Using Tretinoin for Anti-Aging?

It’s never too early or too late for an adult to use tretinoin! Both the short term benefits and the long term benefits are readily visible and worth the effort. 

As examples, I recently had some interesting conversations with two patients, both of whom expressed gratitude for my recommending tretinoin years ago. They both attributed the healthy condition of their skin to their years of tretinoin skin therapy.

The first patient is a woman in her early 60s with rosacea (learn more about rosacea in the rosacea articles I've written about this common skin problem) and a history of skin cancer who said that she had more wrinkles 15 years ago when she started using tretinoin than she does today! Her pores appear smaller and her skin texture is better, both of which she credits to her tretinoin usage.

The second patient just turned 39 and looks like she is in her mid-twenties, no exaggeration. She started using tretinoin when I treated her for acne when she was 27 and also believes she looks better now than she did then. She even said the woman giving her a pedicure on her birthday this year was stunned to find out she was over 30!

Most dermatologists and people who use tretinoin (Retin-A) love it. But it's tricky to use. Here's some of what I've learned over the years as I have helped even the most sensitive complexions tolerate tretinoin:

What You Need to Know About Using Tretinoin Retin-A

  • When you apply tretinoin to moist skin it is more likely to cause peeling and irritation.
  • There is often a skin irritation phase when you first start using Retin-A called a "retinoid dermatitis"
  • Tretinoin, the active ingredient in Retin-A, breaks down in sunlight. This means tretinoin is best used at bedtime.
  • Some of the common and really good ingredients in other skin care products are not compatible with tretinoin.

Tretinoin therapy is well worth the effort in my opinion, but there are tricks to doing it right, including the right supporting products to prevent irritation and support skin hydration and sun protection.

I cover everything you need to know in my guide to how to use tretinoin and build it into your skincare routine.

A Complete Skin Care Kit for Retin-A

I created my Complete Facial Skin Care Kit to work well in a Retin-A tretinoin skin care routine.

best skin care routine with Retin-A tretinoin for acne and antiaging skin care

The kit includes:

  1. Extremely Gentle Foaming Facial Cleanser which is a pH balanced facial cleanser that cleans skin well without irritating or over-drying.
  2. Green Tea Antioxidant Skin Therapy which helps soothe skin irritation and fights skin aging by loading the skin's antioxidant reserve with the best antioxidant for skin care (EGCG-3 polyphenols).
  3. Daily Moisturizing Face Cream which is enriched with barrier supporting ingredients to fight skin dryness.
  4. Sheer Strength Pure Physical Matte Tinted Creme Sunscreen providing pure mineral protection to help prevent skin sun damage and collagen loss.

Tips for Getting the Most Out of Tretinoin

Retin-A Tretinoin is clearly a powerful skin care treatment, but there are tricks for using it to get the greatest benefits. Here’s what I tell my patients:

  1. Always apply tretinoin to your skin at bedtime. Never use it during the day.
  2. Never layer tretinoin with benzoyl peroxide and ideally don't apply it when you also have some of the popular acid products on your skin such as vitamin C or salicylic acid. However, glycolic acid and tretinoin are compatible.
  3. Always wait at least 15-30 minutes after cleansing and applying any other skin care products (such as Green Tea Antioxidant Skin Therapy and/or a simple moisturizer) to your skin before you apply tretinoin to help reduce peeling and dryness.
    apply tretinoin at bedtime
My tube of tretinoin sitting on my bedside table in 2009.

I personally keep my tube of tretinoin on my bedside table and read a little to pass the time before I apply it.

How to Start Using Tretinoin Cream for Anti-Aging and Wrinkles?

Tretinoin often causes peeling and a little skin irritation in the beginning, called 'retinoid dermatitis'.

Over my years of experience with tretinoin I've developed a few more tips to help skin calmly adjust to tretinoin with minimal peeling and irritation from retinoid dermatitis.

Dermatologist Dr. Cynthia Bailey's Tips from Her Practice for Using Retin-A

  • I have my patients apply only a 'pearl-sized' portion of tretinoin to their face. If they are using it on their chest and neck then each get another 'pearl'.
  • I tell my patients that it is important to begin using tretinoin gradually to allow the skin to adjust. I have my patients use it twice a week (every third night) for the first couple of months. During this time, a little scaliness and irritation is normal at first, but if the treated skin becomes really sensitive, I have them back off the tretinoin for a bit. We let their skin return to normal before beginning treatment again. As skin adjusts, we slowly try to increase to using it every night.
  • If skin becomes red and irritated for any reason (e.g., wind burn, sun burned, harsh skin care products, surgical or cosmetic procedures etc.), I instruct my patients not to apply tretinoin until their skin has entirely returned to normal. This is because tretinoin irritates irritated skin!
  • If skin continues to be irritated and just won’t adjust to tretinoin treatment, I switch my patients to an entirely non-irritating skin cleanser like Extremely Gentle Foaming Facial Cleanser. Many other cleansers are simply too irritating for tretinoin-treated skin.
  • Another great trick to help skin love tretinoin is to use Green Tea Antioxidant Skin Therapy. I always add it to the skin care routine when I start a patient on tretinoin. Green tea polyphenol antioxidants are anti-inflammatory and deeply soothing. Sometimes just adding Green Tea Antioxidant Skin Therapy creates all the difference between a positive and a troublesome experience with this great medicine. I recommend that Green Tea Skin Therapy be applied morning and night right after washing and towel drying skin. I have my patients apply tretinoin on top. Click here to learn more about Green Tea Antioxidant Skin Therapy
best soothing skin care product recommended by dr bailey for retin a use

I love all of Dr. Bailey’s products, but if I had to choose just one, I would have to go with the Green Tea Antioxidant Skin Therapy. I love the way it makes my skin feel and keeps my skin from getting all flaky from the Retin-A. Anne F.

It is important to use a really good moisturizer to support your skin's barrier integrity when using tretinoin. This helps reduce peeling and the retinoid dermatitis that some people struggle with. My Daily Moisturizing Face Cream is ideal.

What Are Some Important Precautions with Tretinoin Use?

Since Retin-A can be a tricky medicine, you need to be aware of the following warnings:

  • Tretinoin-treated skin is very exfoliated and should not be waxed for hair removal.
  • Any doctor or skin care specialist performing a procedure such as a chemical peel, microdermabrasion, laser or light treatments, etc., needs to know if you are on tretinoin. It could interfere with your other treatments so they may ask you to stop using it for a period of time before and after your procedure.
  • Anyone who is or may be pregnant should not use tretinoin.
  • It is critically important for anyone using any retinoid to take the strongest precautions in the sun. As mentioned above, skin treated with Tretinoin is very exfoliated. This means that, if tretinoin users do not aggressively embrace sun protection, they will have more sun damage on their skin than if they never used tretinoin. In short, if you use a retinoid, you should wear a really good sunscreen on your treated skin every day.

I am very particular about what sunscreen my retinoid patients use. I recommend only mineral zinc oxide sunscreens because I have found them to be the least likely to irritate tretinoin treated skin and they give the best protection.  

Best skin care routine for tretinoin skin care

Get All the Products You Need

Build a complete your skin care routine and support success with tretinoin for acne and anti-aging skin care in my Complete Facial Skin Care Kit.

It's what I use to support my own treatment with tretinoin.

Are Retinoid Skin Care Products Worth the Trouble?

Scientific studies and my medical experience give me so many reasons to be a big fan of retinoids, including tretinoin. Skin has special receptors just for retinoids (the vitamin A family, of which tretinoin is a member). Through these receptors, tretinoin (and its cousin retinol, which is non-prescription) transform skin!

Retinoid skin benefits:

  • Proven to reduce, reverse, and prevent wrinkles. The younger a person starts (teens and twenties), the more benefit they receive, but it's never too late!
  • Helps to lighten and prevent age spots.
  • Proven to build skin collagen, thickening and increasing the structural strength of treated skin.
  • Helps to reduce crepey skin.
  • Stops the collagen destruction that happens from UV ray exposure.
  • Improves skin appearance, making it quickly look better and younger than before treatment.

Does Tretinoin Cream Help with Crepey Skin?

Yes, tretinoin (Retin-A) cream can help with crepey skin.

What is considered crepey skin? It’s skin that is thin and wrinkled and resembles crepe paper. Crepey skin can happen anywhere including your face, neck, chest, arms and even your knees! We often see it first under and around the thin skin of our eyes.  It is mostly due to aging, menopause, sun damage, and weight loss.

How does tretinoin help treat crepey skin? Tretinoin is a prescription retinoid that increases cell turnover and boosts collagen production. This thickens and plumps the skin, reducing the crepey look. Tretinoin is a retinoid, which is in the vitamin A family. Is it a vitamin for crepey skin? No, but it is a retinoid that can help. 

While tretinoin can improve crepey skin, it's not a miracle cure. It can cause irritation and dryness initially. Consult your dermatologist to find the right tretinoin cream and create a personalized treatment plan.

Follow my tretinoin skin care routine complete with layering options depending on your complexion and the best products to use with tretinoin.

What Skin Care Products Does Dermatologist Dr. Cynthia Bailey Use with Tretinoin Retin-A?

alternate retinol with tretinoin at bedtime

I'm updating this post in 2024. I have used tretinoin now for over 36 years! Holy cow - and I'm still a huge fan. I alternate between tretinoin and my Retinol Anti-Wrinkle Night Cream depending on what my skin wants and if I can wait the 15 minutes or not before falling asleep. But, just about every night my face, neck and chest get a retinoid to sleep with. The science is that convincing and I love how it's helped my skin look better and better over the years.

I'm going to share with you the other key products I combine with my tretinoin and retinol skin care.

My skin can't live without these products and be the same degree of 'happy'. 

best exfoliating facial cleanser to use with tretinoin and retinol

Triple Action Exfoliating Cleanser is the facial cleanser that I use twice a week in the morning to brighten my complexion for the day and to get off any stubborn tretinoin 'peelies'. They make me crazy! I gently massage the scrub onto wet skin and rinse well - off come the eco-friendly exfoliating beads, dead cells and peelies. My skin looks dewy and amazing for a 64+ year old gal. 


best soothing pore shrinking tonerI use my Naturally Hydrating Pore Minimizing Facial Toner on a cotton pad twice a day right after washing. My skin is obsessed with it - soothing, cooling, pore tightening, hydrating and the rose hydrosol is the best subtle scent ever. I searched the world for this hydrosol and it really is the best.

New tinted facial spf 50 with iron oxide



I touch up my SPF during the day with my Sheer Strength Pure Physical Matte Tinted Creme Sunscreen, SPF 50 to be certain my retinoid-treated skin is always UV protected. It's easy to keep this in my purse. The tinting blends with all skin tones and reduces shine from oil or sweat. It also contains iron oxide to help block both visible light and blue light from electronic device screens and that can contribute to skin pigment problems. 

I'm such a tretinoin and retinoid fan that I've created kits to help build the perfect skin care routine to tolerate these powerful age-fighting ingredients. 

My Complete Skin Care Kit has the key products for tretinoin use.

It is built from my personal experience of using tretinoin for over 36+ years and my professional experience helping thousands of people successfully use this great medication. 

best skin care routine to use with Retin A tretinoin

 If you are embarking on tretinoin or retinol treatment I hope you find my tips helpful. I'm a huge fan of retinoids and have used them professionally and personally for 36+ years and counting.

My application photo for my dermatology residency, taken in 1985 when I was about 26 years old, tells the story. Retinoids work! They've really helped this ex-tanning-addicted blond from California. - Dermatologist Dr. Bailey

Please remember that while I am discussing how I use a prescription product in my practice, this information is for informational purposes only. Be certain to discuss tretinoin use with your prescribing physician.

Necessary disclaimer: The information in the Dr. Bailey Skin Care web site, and related links, articles, newsletters and blogs, is provided for general information and educational purposes only. It is the opinion of Dr. Cynthia Bailey, or other indicated authors. Consult your physician or health care provider for any specific medical conditions or concerns you may have. (This also applies to patients in her medical practice; the information here is not a substitute for, or an extension of, the medical care she provides for you.) Never disregard professional medical advice or delay seeking it because of something you have read here. Use the information and products on this site at your own risk. Use of this site indicates your agreement with these statements and the Terms and Conditions of If you do not agree to all of these Terms and Conditions of use, please do not use this site!


Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging. 2006;1(4):327-48. doi: 10.2147/ciia.2006.1.4.327. PMID: 18046911; PMCID: PMC2699641.