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Retinol Intensive Anti-Wrinkle Night Cream 5X
Retinol Intensive Anti-Wrinkle Night Cream
Retinol Ultra Intensive Anti-Wrinkle Night Cream10X
Retinol Ultra Intensive Anti-Wrinkle Night Cream

Retinol Intensive Anti-Wrinkle Night Cream™

$95.50 Regular price
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Retinol is one of the best non-prescription skin care ingredients you can use to reverse the signs of skin aging.

Dermatologists agree that every serious anti-aging skin care routine should include a retinoid product at bedtime. All-trans-retinol is scientifically proven to be the best non-prescription retinoid for the job.

Subscribe and Save: recommended interval every 3 months.

Retinol Intensive Anti-Wrinkle Night Cream is formulated for maximum results in an FDA regulated laboratory using purified and stable, medical grade all-trans-retinol. It's powerful because I aim for results. High strength retinol products contain between 0.5% to 1% retinol denoted as 5X and 10X.

  • Retinol Intensive Anti-Wrinkle Night Cream contains 5X pharmaceutical grade retinol.
  • Retinol Ultra-Intensive Anti-Wrinkle Night Cream contains 10X pharmaceutical grade retinol - the maximal allowed concentration.

In addition, both of my Retinol Night Creams are formulated with green tea antioxidants to bring you maximum retinol effectiveness with minimal skin irritation. They are dispensed in airtight pumps to protect retinol stability. You can't get a better retinol product anywhere. 

In my dermatology practice, I’ve used retinoids for years for their anti-aging benefits. Signs of skin aging can start as early as your late teens; in my opinion, it’s never too early or too late to start using a retinoid. If you are new to retinol, start with my Retinol Intensive Anti-Wrinkle Night Cream. Once your skin has adjusted, you may be able to move up to Retinol Ultra-Intensive Anti-Wrinkle Night Cream.

Improve your complexion quickly and meaningfully with retinol. Dermatologist Dr. Cynthia Bailey

What are the benefits of using a professional high strength retinol product?

  • Improvement of fine lines and wrinkles.
  • Reduction in the appearance of large pores.
  • Reversal of skin thinning from sun damage and age.
  • Helping halt skin collagen breakdown from sun damage and age.
  • Glowing skin by improving skin roughness, dullness, and lack of complexion brightness.
  • Improvement of uneven skin pigment from sun spots, age spots, and melasma.
  • Softening of the appearance of acne scars.
  • Fights clogged pores and blackheads.

When you start using Retinol Intensive Night Cream, you will notice that your complexion brightens right away. You will see smoother and more even skin color, tone, and texture within two weeks. Within four months, you will see improvement in fine lines and wrinkles − and all without a trip to the dermatologist, plastic surgeon, or aesthetician.

What do you need to know about how to you pick the right retinol skin care product?

Not all retinol products are created equal. That’s because retinol is a fragile ingredient and can break down during product processing and packaging. It also works best at higher concentrations; however, at these concentrations retinol can be irritating.

Reap the benefits of retinol without the irritation with my state-of-the-art technology. Retinol Intensive Anti-Wrinkle Night Cream is better tolerated by sensitive skin because:

  • You benefit from the highest concentration of retinol available formulated in a slow-release delivery system; your skin gets all the retinol goodness without being overwhelmed all at once.
  • The synergistic coupling of retinol with high concentration green tea antioxidants helps to calm skin irritation while at the same time enhancing the reversal of sun damage changes in your skin.

See retinol results without irritation.

"I am so thankful I followed your advice."

"Dr. Bailey, you recommended that I should use Retin A or a retinoid type product 24 years ago. I am so thankful I followed your advice. Thank you for all your dermatological words of wisdom. Kristina G



  1. Improvement of Naturally Aged Skin With Vitamin A (Retinol), Reza Kafi, MD; Heh Shin R. Kwak, MD, Arch Dermatol. 2007;143:606-612
  2. Improvement of photoaged facial skin in middle-aged Japanese females by topical retinol (vitamin A alcohol): a vehicle- controlled, double-blind study. Kikuchi K, Suetake T, Kumasaka N, Tagami H, J Dermatolog Treat.2009;20(5):276-81
  3. Choosing Topical Retinoids for Aging Skin, Sachs, DL, Dermatology Focus, Summer 2013 Vol 32 No 2 page 4
  4. Application of Retinol to Human Skin In Vivo Induces Epidermal Hyperplasia and Cellular Retinoid Binding Proteins Characteristic of Retinoic Acid but Without Measurable Retinoic Acid Levels or Irritation, Sewon Kang, Elizabeth A. Duell, et. al., J Invest Dermatol 105:549-556, 1995
  5. Vitamin A Antagonizes Decreased Cell Growth and Elevated Collagen-Degrading Matrix Metalloproteinases and Stimulates Collagen Accumulation in Naturally Aged Human Skin, James Varani, Roscoe L Warner, Mehrnaz Gharaee- Kermani, et. al., J Invest Dermatol (2000) 114, 480-486;
  6. Topical Tretinoin for Photoaged Skin: a Double-blind Vehicle-controlled Study, Weiss JS, Ellis CN, et. al., JAMA.1988, 259: 527-532
  7. Tazarotene Cream for the Treatment of Facial Photo Damage: a Multicenter, Investigator-Masked, Randomized, Vehicle-Controlled, Parallel Comparison of Tazarotene 0.01%, 0.025%, 0.05%, and 0.1% Creams and Tretinoin 0.05% Emollient Cream Applied Once-Daily for 24 Weeks. Kang S, Leyden JJ, Lowe NJ, et al., Arch Dermatol. 2001;137:1597- 1604.
  8. Mechanisms of Photoaging and Chronological Skin Aging, Gary J. Fisher, PhD; Sewon Kang, MD; et. al., Arch Dermatol. 2002;138(11):1462-1470

Key Ingredients:

  • purified and stable, medical grade all-trans-retinol at .5 and 1% concentrations
  • 80-90% pure green tea polyphenol antioxidant isolates,
  • hyaluronic acid.

Dispensed in an airtight pump.

Free of:

  • fragrance,
  • oil,
  • parabens,
  • sulfates,
  • SLS, 
  • formaldehyde, 
  • phthalates.


Always cruelty-free and made in the USA.

cruelty-free medical grade skin care

Understanding Retinol

You may not be familiar with retinol and why it is an integral component to a Complete Skin Care Routine™. Here are some facts you should know:

  • Retinol is part of a family of agents called retinoids. While these compounds all have similarities, they don’t all work equally well to reverse the signs of skin aging.
  • Retinol is vitamin A. It is converted in the skin to retinoic acid, the active ingredient in Retin A and Renova (also called tretinoin). Evidence suggests that it is the most effective non-prescription retinoid for reversing the signs of skin aging.
  • The skin contains specific receptors that bind retinoids to create beneficial changes that brighten your complexion and fight skin aging and sun damage.

Know What to Expect from Retinoid Products

You will notice some skin changes when you start using a stable, high concentration retinoid product such as Retinol Intensive Anti-Wrinkle Night Cream. These changes include:

  • A brighter complexion within a week. This happens because the dead skin layer called the stratum corneum becomes more compact brightening your complexion and smoothing skin roughness. The living cell layer called the epidermis begins to thicken and show evidence of swelling (spongiosis), which means a dewier and more youthful complexion.
  • A dewier complexion within two weeks. Retinoids stimulate skin to make more hyaluronic acid in your skin's living layers, resulting in deeper skin hydration with more hydrated skin tone and texture and further youthening in the appearance of your skin.
  • More even skin color during the first ten months. Retinol is proven to improve uneven skin pigment including sun spots, brown age spots, and other forms of hyperpigmentation such as melasma.
  • Reduction in the appearance of fine lines and wrinkles after four months. Numerous scientific studies have shown improved collagen production in the skin with retinoid use. This equates to meaningful improvements in the appearance of fine lines and wrinkles and in skin thinning.

All dermatologists agree that retinoids are an integral part of any meaningful age-fighting skin care routine. Add state-of-the-art Retinol Intensive Anti-Wrinkle Night Cream to your complete anti-aging skin care routine for healthier younger looking skin.

All retinoids, including retinol, work best when you apply it at night. This is because retinoids break down upon contact with light.

In the evening,

  1. Cleanse your skin with your favorite cleanser and towel dry.
  2. Apply a pea-sized amount of my Retinol Intensive or Ultra-Intensive Anti-Wrinkle Night Cream. You can use another pea-sized amount for your neck and another for your chest if your skin can tolerate it. Start "low and slow" with retinol. See my tips below.
  3. Layer a richer moisturizer on top of the Retinol Night Cream such as one of my Daily Moisturizing Face Creams.

Pro Tip: You can combine retinol products with glycolic acid if your complexion can tolerate it. Both of these age-fighting ingredients accomplish similar skin transformation but by different mechanisms. Thus, the results can be additive! I recommend applying my Glycolic Acid Anti-Wrinkle Face Cream on top of my Retinol Intensive Anti-Wrinkle Night Cream. This is what I personally do when my sensitive skin will let me.

I don't recommend applying other powerful ingredients such as benzoyl peroxide, salicylic acid, or vitamin C at the same time as retinoids. Save those ingredients for your daytime skin care routine or alternate them with the Retinol Night Cream.

Why is it important to start "low and slow" with powerful professional skin care products such as retinol?

Retinol is one of the important skin care ingredients that can irritate skin until a complexion has adjusted and transformed to tolerate the ingredient. Help your skin adjust by starting on lower concentrations and slowly working up to daily use:

  • Start by using my Retinol Night Cream every third night.
  • As your skin adjusts, you can increase your use to every-other night, and then a nightly application.
  • If for any reason, on any portion of your treated skin, you develop irritation - take a break; stop applying the Retinol Cream until your skin is back to normal for a week then resume at a less frequent rate and again work up to nightly use.
  • There may be parts of your face that are more prone to irritation such as around your mouth or nose or the creases of your eyelids. If you find that to be true, use the cream less often there or not at all.

Precautions with using retinoids:

  • Remember to wear a broad spectrum sunscreen on retinoid treated skin during the day.
  • Retinoids, including retinol, are not recommended for use during pregnancy. 
  • Retinoid treated skin will be more exfoliated than untreated skin so remember to tell your skin care professional before having treatments done on the areas of skin where you are applying a retinoid. This includes waxing, face peels etc.
  • Exercise caution when using any skin care product that can be abrasive or irritating on skin where you are using a retinoid. 

My "low and slow" philosophy with professional skin care products is especially important with powerful retinol creams. I recommend starting with retinol every third night and slowly increasing to every night as your skin adjusts.  If you skin becomes chapped for any reason (wind, products, procedure etc.), don't apply retinol until your skin is back to normal. 

Still not sure about retinol skin care products? Click here to learn more about this important ingredient.

Retinol Intensive Anti-Wrinkle Night Cream (1 fl. oz.) 5X (0.5%)

Cyclopentasiloxane, Caprylyl Methicone, Dimethicone Crosspolymer, PEG-12 Dimethicone/PPG-20 Crosspolymer, Dimethicone, Caffeine, PEG/PPG-18/18 Dimethicone, Camellia Sinensis (Green Tea) Polyphenols, Retinol, Sodium Hyaluronate, Polysorbate 20, Cyclomethicone.

Retinol Ultra Intensive Anti-Wrinkle Night Cream (1 fl. oz.) 10X (1.0%)

Cyclopentasiloxane, Caprylyl Methicone, Dimethicone Crosspolymer, PEG-12 Dimethicone/PPG-20 Crosspolymer, Dimethicone, Caffeine, PEG/PPG-18/18 Dimethicone, Camellia Sinensis (Green Tea) Polyphenols, Retinol, Sodium Hyaluronate, Polysorbate 20, Cyclomethicone.

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